Overdominance
Overdominance - Wikipedia, the free encyclopedia
Overdominance is a condition in genetics where the phenotype of the heterozygote ... Retrieved from "http://en.wikipedia.org
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Dominance versus overdominance - Wikipedia, the free encyclopedia
Dominance versus overdominance is a scientific ... Overdominance hypothesis. ... The overdominance hypothesis attributes to heterozygote advantage the survival ...
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Articles About Overdominance | HighBeam Research
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overdominance: Definition from Answers.com
overdominance n. The condition of a heterozygote having a phenotype that is more pronounced or better adapted than that of either homozygote
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Inferring the major genomic mode of dominance and overdominance
Determining whether dominance or overdominance ... compatible with associative overdominance, an arti ... overdominance) ...
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Testing overdominance in MHC: Can it be done? | Mystery Rays from Outer ...
Malaria parasites in mosquito midgut Why is it so hard to come up with a ... Overdominance was (as far as I know) the first mechanism put forward to explain ...
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Evolution
This has been called associative overdominance (Ohta 1971 ; Pamilo and Pálsson 1998 ) ... model of associative overdominance during a population bottleneck. ...
plantecology.dbs.umt.edu
Effect of human leukocyte antigen heterozygosity on infectious disease ...
To demonstrate allele-specific overdominance for specific infections in human ... It can also accommodate overdominance of the resistant alleles (a > 1; b >d; c > ...
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GenCB 511 "COARSE" Notes Population Genetics IV-7 O
... called, respectively, overdominance and underdominance in ... Stable for overdominance; Unstable (non-oscillatory) for ... Overdominance maintains ...
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Gene Expression: Why overdominance ain't all that
A few days ago I posted about how overdominance, the fitness advantage of a heterozygote (an Aa genotype instead of an AA or aa genotype), can maintain ...
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Overdominance is an alternate term for heterozygote advantage, a condition in genetics where the phenotype of the Zygosity is fitter than the phenotype of either Zygosity. The concept of overdominance has been used by plant breeders crossing inbred strains and selecting for desired characteristics. The theory that heterosis or hybrid vigor could be explained by heterozygote advantage became known as the overdominance hypothesis.
Hybrid vigor in plants When a population is small or inbred, it tends to lose genetic diversity. Selective breeding of plants and animals, including hybridization, began long before there was an understanding of underlying scientific principles. In the early 20th century, after Mendel's laws came to be understood and accepted, geneticists undertook to explain the superior vigor of many plant hybrids. Two competing hypotheses, which are not mutually exclusive, were developed:
- Dominance hypothesis. Inbred strains tend to be homozygous for recessive alleles that are mildly harmful (or produce a trait that is undesirable from the standpoint of the breeder). This phenomenon is known as inbreeding depression. The dominance hypothesis attributes the superiority of hybrids to the suppression of undesirable recessive alleles from one parent by dominant alleles from the other. It attributes the poor performance of inbred strains to loss of genetic diversity, with the strains becoming purely homozygous at many loci.
- Overdominance hypothesis. Certain combinations of alleles that can be obtained by crossing two inbred strains are advantageous in the heterozygote. The overdominance hypothesis attributes to heterozygote advantage the survival of many alleles that are recessive and harmful in homozygotes. It attributes the poor performance of inbred strains to a high percentage of these harmful recessives.
Population geneticist James F. Crow, who in his younger days believed that overdominance was a major contributor to hybrid vigor, has undertaken a retrospective review of the developing science. According to Crow, the demonstration of several cases of heterozygote advantage in Drosophila and other organisms first caused great enthusiasm for the overdominance theory among scientists studying plant hybridization. But overdominance implies that yields on an inbred strain should decrease as inbred strains are selected for the performance of their hybrid crosses, as the proportion of harmful recessives in the inbred population rises. Over the years, experimentation in plant genetics has proven that the reverse occurs, that yields increase in both the inbred strains and the hybrids, suggesting that dominance alone may be adequate to explain the superior yield of hybrids. Only a few conclusive cases of overdominance have been reported in all of genetics. Since the 1980s, as experimental evidence has mounted, the dominance theory has made a comeback.
Crow writes, "The current view ... is that the dominance hypothesis is the major explanation of inbreeding decline and the high yield of hybrids. There is little statistical evidence for contributions from overdominance and epistasis. But whether the best hybrids are getting an extra boost from overdominance or favorable epistatic contributions remains an open question."
Overdominance in human genetics In humans, sickle cell anemia is a condition that is determined by a single polymorphism (biology). Heterozygotes have superior resistance to malaria, an important fitness advantage in malarial regions.
Genetic basis of heterosis {| width="565" height="289" align="right" border="1"|-----! width="92" scope="row" | | width="115" | Parental genotypes (homozygous) | width="95" | Gene expression profile | width="131" | Offspring genotype (heterozygous)| width="98" | Gene expression profile |-----! rowspan="2" scope="row" | Scenario A | bordercolor="#2A3F00" | AA| bordercolor="#2A3F00" | 1| bordercolor="#2A3F00" | Aa| bordercolor="#2A3F00" | 1|-----| bordercolor="#2A3F00" | aa| bordercolor="#2A3F00" | 0| bordercolor="#2A3F00" | | bordercolor="#2A3F00" | |-----! colspan="5" scope="row" | |-----! rowspan="2" scope="row" | Scenario B| bordercolor="#2A3F00" | AA| bordercolor="#2A3F00" | 1| bordercolor="#2A3F00" | Aa| bordercolor="#2A3F00" | 2|-----| bordercolor="#2A3F00" | aa| bordercolor="#2A3F00" | 1| bordercolor="#2A3F00" | || bordercolor="#2A3F00" | |-----| colspan="5" scope="row" | Dominance hypothesis . Scenario A . Less genes are under expressed in the homozygous individual. As well, gene expression in the offspring is equal to the expression of the best parent. Over dominance hypothesis . Scenario B . Over expression of certain genes in the homozygous. Legend 0 = low or no expression of gene A 1 = normal expression of gene A 2 = over expression of gene A |} The two hypotheses (dominance and overdominance) will have different consequences on the gene expression of the individuals. If over-dominance is the main cause for the fitness advantages of heterosis, then there should be an over-expression of certain genes in the heterozygous offspring compared to the homozygous parents. On the other hand, if dominance is the cause, then there should be fewer genes that are under-expressed in the heterozygous offspring compared to the parents. Furthermore, for any given gene, the expression should be comparable to the one observed in the best of the two parents.
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